Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients

Launched by ANKARA CITY HOSPITAL BILKENT · Feb 15, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how certain medications called statins, which are commonly used to lower cholesterol, affect muscle relaxation during surgery. When patients undergo general anesthesia for elective surgeries, their muscles are often relaxed using a method called neuromuscular blockade. The study will compare patients who have been using statins for at least three months with those who have not used them at all. The researchers want to find out if statin use changes how deeply the muscles are relaxed, how long it takes for them to recover, and whether any muscle relaxation remains after surgery.

To participate in this study, you need to be between 18 and 75 years old, in good health (classified as ASA I, II, or III), and have a body mass index (BMI) between 18 and 30. You should also be scheduled for surgery that requires general anesthesia. If you have certain health issues, such as severe liver or kidney problems, respiratory disorders, or a history of certain muscle disorders, you may not be eligible. Participants will be asked to sign a consent form, and during the study, they will be monitored closely to assess how well their muscles respond to the anesthesia. This research aims to improve our understanding of how statins may impact muscle function during surgeries, which can help doctors provide better care for their patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18-75 years
• • ASA classification I, II, III
• • BMI 18-30
• • Statin use for at least 3 months or no prior statin use
• • Elective surgery requiring general anesthesia with endotracheal intubation
• • Signed informed consent for participation in the study
• Exclusion Criteria:
• • ASA classification IV or higher
• • BMI \<18 or \>30
• • History of liver or renal insufficiency (creatinine \>1.6, liver function tests \>2x normal)
• • Neuromuscular, psychiatric, or neurological disorders
• • Pregnancy
• • Use of drugs affecting neuromuscular function (e.g., anticonvulsants, aminoglycosides)
• • History of malignant hyperthermia
• • Respiratory disorders, including sleep apnea
• • Allergy to anesthetic drugs used in the study