Trending Ability of End-Tidal Capnography to Reflect Arterial Carbon Dioxide Changes in One-Lung Ventilation
Launched by KOÇ UNIVERSITY · Feb 14, 2025
Trial Information
Current as of July 01, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating whether measuring carbon dioxide in a patient’s breath (called end-tidal CO₂ or ETCO₂) can accurately reflect changes in carbon dioxide levels in the blood (known as arterial CO₂ or PaCO₂) during lung surgery. In this type of surgery, patients often use "one-lung ventilation," which means one lung is used for breathing while the other is temporarily deflated. This can lead to changes in carbon dioxide levels that are usually monitored by taking blood samples. The study aims to see if the trends in ETCO₂ align with those in PaCO₂ over time, which could help doctors reduce the number of blood tests needed.
To be eligible for this trial, patients must be undergoing thoracoscopic lung surgery with one-lung ventilation and require a small tube in an artery for monitoring blood pressure. However, patients with chronic lung diseases, pulmonary hypertension, or systemic infections will not be included. Participants will have their blood carbon dioxide levels compared to their breath measurements at the same time, and additional health information like heart rate and body temperature will also be monitored. This research could lead to a simpler and less invasive way to monitor carbon dioxide levels during lung surgery.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients undergoing thoracoscopic lung surgery with one-lung ventilation
- • Patients requiring invasive arterial blood pressure monitoring
- Exclusion Criteria:
- • Chronic obstructive pulmonary disease (COPD)
- • Pulmonary hypertension
- • Systemic infection
About Koç University
Koç University, a leading multidisciplinary research institution located in Istanbul, Turkey, is dedicated to advancing healthcare through innovative clinical research. With a commitment to excellence in education and research, the university fosters collaboration among experts in various fields, aiming to translate scientific discoveries into practical applications that improve patient outcomes. Koç University’s clinical trial initiatives are characterized by rigorous methodologies, ethical standards, and a focus on addressing pressing health challenges, positioning it as a pivotal player in the global research landscape.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported