Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury

Launched by MANSOURA UNIVERSITY · Feb 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two types of medications, propranolol and carvedilol, on patients who have suffered a traumatic brain injury (TBI). The goal is to see how these beta blockers might help improve recovery and reduce further brain damage in patients who have moderate to severe TBIs. Researchers believe that these medications might work differently based on how they interact with certain receptors in the body, which could lead to different outcomes for patients.

To participate in this trial, patients need to be between the ages of 18 and 74 and have a moderate to severe TBI, as shown by a CT scan and a specific scoring system called the Glasgow Coma Scale (GCS). They should not have any significant other injuries. However, those who were already taking beta blockers before their injury or have certain serious health conditions are not eligible. Participants will receive the study medication and will be monitored closely to see how it affects their recovery. This research is important as it could help improve treatment options for future patients with similar injuries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with moderate \& severe TBI detected on admission by CT scan and GCS score of ≤ 13 who either do not have any other injuries or only have associated minor injuries.
• Minor injuries are defined as presence of any of the following:
• • 1. Mild intraperitoneal free fluid (IPFF) observed through abdominal ultrasound.
• • 2. mild lung contusion detected in the chest CT scan.
• • 3. hemothorax or pneumothorax present without accompanying symptoms of hypoxia, tachypnea, or respiratory distress.
• • 4. simple limb fractures.
• Exclusion Criteria:
• • 1. Patients on pre-injury beta-blocker therapy.
• • 2. Patients with any bronchospastic conditions.
• • 3. Patients with active acute coronary syndrome.
• 4. TBI with GCS ≤ 13 with associated major injuries defined as the presence of any of the following:
• • 1. Moderate \& marked IPFF requiring surgical intervention ( laparotomy ).
• • 2. moderate \& marked lung contusion, pneumothorax \& hemothorax with accompanying symptoms of hypoxia, tachypnea, lower limbs, or limb amputation.
• • 3. Compound fracture in the upper or lower limb.
• • 4. Open Faciomaxillary trauma.
• • 5. Patients with persistent shock (systemic blood pressure \<100 mmHg, base deficit \> 4, or oliguria , HR \< 60 b/min ) after \> one week of admission.