The Effect of Vicia Faba Hydrolysate Supplementation on Muscle Strength Recovery

Launched by PEPSICO GLOBAL R&D · Feb 14, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at whether a special protein supplement made from fava beans, called PeptiStrong®, can help with muscle recovery after exercise. The study will involve participants taking either the supplement or a placebo (a harmless pill with no active ingredients) for 14 days, followed by a challenging exercise session. For the last three days of the study, some participants will continue taking the same treatment, while others will switch from the placebo to the supplement.

To join the trial, participants should be healthy men and women aged 18 to 45 who exercise moderately a few times a week. They should be willing to avoid other protein supplements and certain foods during the study. Participants will need to fast overnight on testing days and complete questionnaires about their experiences. Throughout the trial, they will continue with their regular diet and light exercise. It’s important for potential participants to know that those with certain health conditions, such as specific genetic issues related to fava beans, or who are pregnant or using certain medications, won’t be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Males and females 18 - 45 years of age.
• • Willing to fast overnight on the 4 testing occasions.
• • Participants agree to abstain from taking additional supplements throughout the testing period, with particular emphasis placed upon protein-based products (e.g., whey or casein based protein powders; animal derived protein hydrolysates; natural supplements constituted of vegetative protein hydrolysates from rice, fava bean, pea, carrot, spirulina, broccoli, potatoes; marine derived secondary metabolite products or protein hydrolysates including Omega-3 capsules or DHA).
• • Moderately active (exercise 3-5 days per week)
• • Fluent in reading, writing, and speaking English
• • Participants agree to maintain their normal diet and perform only light to moderate exercise for the duration of the study.
• • BMI between 18.5 and 29.9 kg/m2
• • Participants agree to refrain from consuming alcohol in the 48 hours leading up to a test day.
• • Willingness to complete questionnaires, records and diaries associated with the study and to complete all lab visits.
• • Refrain from any exercise from 48 hours prior to each test or blood draw.
• • Healthy as determined by General Health Questionnaire.
• • Non-smoker
• Exclusion Criteria:
• • Individuals that are glucose-6-phosphate-dehydrogenase deficient. The test product in this study contains fava bean extract which may produce favism in genetically susceptible individuals.
• • Alcohol or drug abuse in the past year.3. Testosterone or estrogen supplementation (not including women on oral contraceptives)
• • Pregnant or nursing or planning to become pregnant.
• • Participation in any other clinical trial in the past 30 days. Participation in any PepsiCo trial in the past 6 months
• • Volunteers with unstable medical conditions.
• • Any complaints that could interfere with the ability to exercise.
• • Individuals who are cognitively impaired or unable to give informed consent.
• • Any co-morbidities interacting with mobility or muscle metabolism of the lower limbs (e.g. arthritis, spasticity / rigidity, all neurological disorders, paralysis).
• • Creatine supplements, corticosteroids, NSAIDS, amino acids, injectible peptides, collagen, and nicotinamide (Vit B3/niacin).
• • Presence or history of neurological disorders or significant psychiatric illness.
• • Any condition the study investigator believes would interfere with eligibility following the study protocol, effect the study results, or put the subject at undue risk.
• • Participation in resistance or aerobic exercise within 48 hours of the test days.
• • Participation of \>3 high-intensity exercise sessions per week.
• • Undertake recovery methods such as sea swims, foam rolling, cryotherapy or excessive stretching during days 14-17.
• • Have been in contact with a suspected or confirmed case of COVID-19 in previous 14 days.
• • Are Hepatitis A- or B-positive or have had a sexual partner infected with hepatitis or HIV and not taking medication.
• • Are not employed by, or have a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If you are unsure if a company would be considered a competitor to Gatorade, let the study investigator know the name of the other company and the nature of your relationship to that company before ou sign the informed consent