To Explore the Optimal Dose of Dexmedetomidine for Skull Pin Fixation in Intracranial Surgery

Launched by KAOHSIUNG MEDICAL UNIVERSITY CHUNG-HO MEMORIAL HOSPITAL · Feb 19, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at the best dose of a medication called dexmedetomidine to help manage pain during a specific procedure known as skull pin fixation in brain surgery. This procedure can be quite uncomfortable and can lead to high heart rates and blood pressure, so finding an effective way to reduce this pain and stabilize vital signs is important. The study will use a special pump that can adjust the medication automatically based on each patient's needs, ensuring they receive the right amount for their comfort and safety.

To participate in the trial, individuals must be between 18 and 80 years old and are scheduled for intracranial surgery that requires skull pin fixation. Those who are not eligible include younger patients, older patients over 80, and those with certain health conditions or allergies to the medications being tested. Participants can expect to receive careful monitoring during the procedure to evaluate how well the dexmedetomidine works in managing pain and maintaining stable heart rates and blood pressure. This research aims to improve anesthesia practices for future surgeries, making them safer and more comfortable for patients.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Must be at least 18 years old and less than 80 years old, with ASA I\~III. Patients who are expected to undergo intracranial surgery for skull pin fixation.
• Exclusion Criteria:
• • Patients under the age of 18, patients over 80, those who have not signed a consent form, those with ASA class IV or higher, those who are allergic to dexmedetomidine or propofol or remifentanil, sever bradycardia (HR\<40 bpm), hypotension (\<90/60 mmHg) and hypertension crisis (180/110 mmHg), and emergency patients, etc.