Incidence, Characterisation and Outcome-relevance of Perioperative SGLT2 Inhibitor Associated Ketoacidosis

Launched by HEINRICH-HEINE UNIVERSITY, DUESSELDORF · Feb 17, 2025

Keywords

ClinConnect Summary

This clinical trial is designed to study a condition called ketoacidosis that can occur in patients taking a type of medication known as SGLT2 inhibitors. These medications help control blood sugar levels in people with diabetes. The trial aims to find out how often ketoacidosis happens in adults who have taken SGLT2 inhibitors in the three months before having surgery, as well as how it is managed during and after the surgery. Researchers will also look at how fasting times (the time without food) affect these patients and the overall outcomes of their surgeries.

To be eligible for this study, participants must be at least 18 years old, have been prescribed and regularly taken an SGLT2 inhibitor in the past three months, and be undergoing a surgical procedure that requires at least one night in the hospital afterward. If someone is not able to give consent or is having outpatient surgery (not requiring a hospital stay), they would not be included in the study. This research is not yet recruiting participants, but it will provide valuable information to help doctors prevent and manage ketoacidosis in patients undergoing surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Prescription and regular intakte of any SGLT2 inhibitor within the last three months (regardless if SGLT2 inhibitor was discontinued preoperatively or not)
• • Surgical procedure
• • At least one overnight stay in the hospital following surgery
• • Age \>= 18 years
• Exclusion Criteria:
• • Unwilling and/or unable to consent
• • Outpatient surgery