A Study of HS-20094 in Chinese Adults with Overweight or Obesity

Launched by JIANGSU HANSOH PHARMACEUTICAL CO., LTD. · Feb 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new medication called HS-20094 to see how well it works and how safe it is for adults in China who are overweight or obese. The trial will last about 52 weeks, and it aims to help people manage their weight more effectively.

To join the study, participants need to be between 18 and 65 years old with a body mass index (BMI) of 28 or higher, or a BMI of 24 or higher if they have certain health conditions like prediabetes or high blood pressure. Before joining, they should have tried diet and exercise for at least 12 weeks without losing more than 5% of their weight. Participants will be closely monitored throughout the trial, and anyone with certain health issues, such as diabetes or a history of severe depression, will not be eligible. This study could provide valuable insights into new ways to support weight management for those struggling with obesity.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1.Male or female 18 to 65 years of age at the time of consent(cutoff value included).
• • 2. Body mass Index(BMI)≥28 kilograms per square meter(kg/m2),or ≥24 kg/m2 and previous diagnosis with at least one of the following comorbidities: prediabetes, hypertension, dyslipidemia, non-alcoholic fatty liver disease, obstructive sleep apnea.
• • 3. Weight change ≤5.0% after diet and exercise control for at least 12 weeks before screening.
• Exclusion Criteria:
• • 1. Diabetes mellitus 2. Weight change \>5.0% after diet and exercise control for at least 12 weeks before screening 3. Have used or are currently using weight loss drugs within 3 months before screening 4. History of pancreatitis 5. Family or personal history of medullary thyroid carcinoma(MTC)or multiple endocrine neoplasia syndrome type 2(MEN-2) 6. History of moderate to severe depression, or have a history of serious mental illness 7. Any lifetime history of a suicide attempt 8. Have a history of significant atopy (severe allergic manifestations), multiple or severe drug allergies, or severe posttreatment hypersensitivity reactions 9. Have a history of any malignancy within the past 5 years