Association Between Genetic Polymorphisms and Type 2 Asthma in Children

Launched by GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE · Feb 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the connection between certain genetic factors and type 2 asthma in children. Researchers want to understand how specific changes in genes might affect how children develop asthma related to inflammation, which is when the lungs become irritated and swollen. By looking at these genetic changes, along with lung function and signs of inflammation, the goal is to help create better, personalized treatments and prevention strategies for asthma in kids.

To join this study, children must have a diagnosis of asthma that meets the current guidelines and should not have other health issues that could cause similar symptoms, like severe throat infections or congenital airway problems. Participants should not have been on antibiotics or strong steroids for at least two weeks before joining. It’s important that the children and their families are willing to cooperate with the study. Those who have been on certain medications for a long time or have specific immune system conditions will not be eligible. If your child qualifies, they can expect to undergo tests to help researchers learn more about the role of genetics in asthma.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. All children with asthma diagnosis accord with the GINA in 2023 edition;
• • 2. Other diseases that could cause wheezing and cough were excluded, such as acute laryngitis, diphtheria, congenital airway abnormalities, and tracheal foreign bodies;
• • 3. In front of the hospital 2 weeks without antibiotics, systemic hormone medication history;
• • 4. There were no other complications, such as congenital heart disease, pneumonia, gastroesophageal reflux disease, muscle dysplasia, etc.
• Exclusion Criteria:
• • 1. Children who had taken immunosuppressants, antibiotics and other drugs for a long time before admission;
• • 2. Children with primary immunodeficiency disease;
• • 3. The children and their families failed to cooperate or refused the experimental observation.