Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes

Launched by MICHELLE ZELLER · Feb 19, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how the sex of blood donors may affect how well patients do after receiving red blood cell (RBC) transfusions. Currently, blood transfusions are mostly based on matching blood types, without considering whether the donor and recipient are the same sex. Some research suggests that matching the donor's sex to the recipient's could improve patient outcomes. In this study, adult patients in the Intensive Care Unit (ICU) who need a blood transfusion will be randomly assigned to receive either sex-matched or sex-mismatched RBCs. The goal is to see if there are differences in survival rates between the two groups.

To be eligible for this trial, participants must be adults aged 18 or older, currently admitted to a participating ICU, and require an RBC transfusion. However, those with rare blood types or who are experiencing severe bleeding won't be included. If you or a loved one meets the criteria, you can expect to be part of a study that could help improve future blood transfusion practices and potentially save lives. The trial is not yet recruiting participants, but it aims to gather important information that could change how blood transfusions are ordered and managed in hospitals.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (age ≥18);
• • Admission to a participating ICU;
• • Requiring RBC transfusion.
• Exclusion Criteria:
• • Requirement for a specialized RBC product or unit not readily available in inventory (e.g., rare blood type, washed RBCs, complex RBC antibodies, etc.);
• • Massively bleeding patient (i.e., ≥4 units of blood ordered at one time, or Massive Hemorrhage Protocol initiated, or an urgent blood request made);
• • Sex unknown or sex other than male or female (i.e. intersex);
• • Do not have a valid Ontario Health Insurance Plan (OHIP) health card number.