Role of Corneal Nerves in Dry Eye Disease

Launched by DANIELA NOSCH · Feb 21, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating the role of corneal nerves in people with Dry Eye Disease (DED). Researchers want to understand how the health and function of these nerves are affected by problems with tear production and the overall condition of the eye surface. They are also looking to see if these factors change depending on how severe someone's dry eye symptoms are.

If you're between the ages of 65 to 74 and have been diagnosed with dry eye disease, or if you do not have dry eye disease, you may be eligible to participate. Before your first visit, if you wear contact lenses, you'll need to stop using them for a week. During the study, you'll be asked not to use certain eye drops or makeup on the day of your examination. Participants will help researchers learn more about dry eye disease, which could lead to better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Group with DED: Diagnosis of DED based on the TFOS DEWS II report
• • Group without DED: No diagnosis of DED
• Exclusion Criteria:
• * Exclusion criteria:
• • Systemic disease that may affect ocular health and innervation
• • injury or history of operations on the anterior or posterior segment of the eye, which can affect the corneal structure and physiology
• • regular application of systemic or ocular medication known to affect the tear film except from DED medications
• • eye drops or makeup on the day of measurement.
• Remarks:
• • Contact lens wearers are asked not to wear contact lenses for 1 week before the first appointment.
• • Participant with DED medications will be asked to use only conservative-free eye drops on the days of examination