Combined Effects of Statins and Exercise on Training Sensitive Health Markers

Launched by UNIVERSITY OF THE FAROE ISLANDS · Feb 19, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how taking statin medications, which help lower "bad" cholesterol levels, affects the benefits of exercise in people with abnormal blood fat levels, known as dyslipidaemia. Researchers want to understand if the combination of statins and a structured exercise program can improve muscle health and overall fitness. The study will involve 100 adults aged 40 to 65 who have high cholesterol but no heart disease. Participants will be placed into different groups where some will exercise while taking statins or a placebo, and others will not exercise but still take statins or a placebo.

To be eligible for the trial, participants must be between 40 and 65 years old and have a specific level of bad cholesterol. However, those with serious health issues, such as diabetes, cancer, or severe mental health conditions, will not be able to participate. Throughout the 12-week program, participants can expect to undergo fitness tests and evaluations of their muscle cell function. The study has ethical approval to ensure the safety and rights of participants, and once completed, the findings will be shared with the public and medical community to help improve health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: 40-65 years
• • LDL-C \> 4.0 mmol/L.
• Exclusion Criteria:
• • Diagnosed with serious chronic disease including type 1 or 2 diabetes.
• • Cancer.
• • A history of atherosclerotic cardiovascular disease.
• • A history of major depression or other severe psychiatric disorders.
• • Severe renal dysfunction (creatinine clearance \<30 mL/min).
• • Severe hepatic impairment.
• • Active pregnancy or breast feeding.
• • Active cigarette or e-cigarette smoker.
• • Regular (\>2 hours pr week) aerobic high-intensity exercise training.