Intravenous Thrombosis and Patients with Prior Ischemic Stroke Within 3 Months

Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Feb 20, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how effective a treatment called intravenous thrombolysis (a medicine given through a vein to dissolve blood clots) is for patients who have had a stroke and had a previous stroke within the last three months. The researchers believe that this treatment could help improve recovery for these patients compared to standard care practices.

To be part of this study, participants need to be at least 18 years old and show signs of an acute ischemic stroke (when a blood clot blocks blood flow to the brain) within 24 hours. It's important that they have also experienced a prior stroke in the last three months. However, some individuals may not be eligible if they have certain medical conditions, like recent severe head trauma or bleeding issues. Those who join the trial will receive close monitoring and care to see how well the treatment works for their recovery. This trial is not currently recruiting participants, but it aims to gather valuable information about improving stroke treatment in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with clinical signs of acute ischemic stroke within 24 hours of onset or awakening with stroke (if within 24 hours from the midpoint of sleep). Patients with AIS within 4.5-24 hours of onset must meet the IVT inclusion criteria specified in the guideline
• • 2. Patients with prior ischemic stroke within 3 months
• • 3. Patients ≥ 18 years old
• • 4. Informed consent has been obtained depending on local ethics requirements.
• Exclusion Criteria:
• • (1) Plan to receive endovascular treatment (2) Pre-stroke mRS score \> 2 (3) Contraindications for IVT：
• • 1. Intracranial hemorrhage (including parenchymal hemorrhage, intraventricular hemorrhage, subarachnoid hemorrhage, epidural hematoma, etc.)
• • 2. Previous history of intracranial hemorrhage
• • 3. Severe head trauma or stroke history within the last 3 months
• • 4. Intracranial tumors, giant intracranial aneurysms
• • 5. Intracranial or spinal surgery within the recent 3 months
• • 6. Major surgical procedures within the last 2 weeks
• • 7. Gastrointestinal or urinary tract bleeding within the last 3 weeks
• • 8. Active visceral bleeding
• • 9. Aortic arch dissection
• • 10. Arterial puncture in a site within the last 1 week that is not easy to compress and stop bleeding
• • 11. Elevated blood pressure: Systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 100 mmHg
• • 12. Acute bleeding tendency, including platelet count \< 100 × 10⁹/L or other conditions
• • 13. Received low-molecular-weight heparin treatment within 24 hours
• • 14. Oral anticoagulants (warfarin) with INR \> 1.7 or PT \> 15 s; Receiving heparin treatment with aPTT above the upper limit of the normal range within the last 24 hours of onset, Receiving thrombin inhibitors and factor Xa inhibitors within the last 48 hours of onset.
• • 15. Blood sugar \< 2.8 or \> 22.22 mmol/L
• • 16. Head CT or MRI indicates large-area infarction (infarction area ≥ 1/3 of the middle cerebral artery supply area) (4) The judgment is left to the discretion of the investigator