Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease

Launched by ZHANG LONGJIANG,MD · Feb 19, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether using a specific type of imaging called coronary computed tomography angiography (CCTA) can help doctors better manage patients with non-obstructive coronary artery disease (CAD). The goal is to see if this imaging approach can help patients reach their cholesterol targets and, ultimately, reduce the risk of serious heart and brain problems over three years. These problems can include heart attacks, strokes, and other major health events.

To join the trial, participants need to be between 18 and 80 years old and have been diagnosed with non-obstructive CAD for at least two years. It's important that they are willing to have follow-up CCTA scans and participate in ongoing observations. However, people who have had recent heart attacks, certain heart surgeries, or other serious health issues may not qualify. If you decide to participate, you can expect to undergo CCTA scans and work closely with the research team to monitor your heart health over time. This study aims to find better ways to prevent major cardiovascular events and improve patient care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 18 and 80 years old;
• • 2. Known patients with non-obstructive coronary artery disease (disease duration ≥2 years);
• • 3. Patients who agree to undergo follow-up CCTA examinations and cooperate in completing follow-up observations.
• Exclusion Criteria:
• • 1. Patients who have experienced ACS or PCI/CABG;
• • 2. Patients who have experienced adverse cardiovascular and cerebrovascular events;
• • 3. Patients who have undergone follow-up CCTA or DSA examinations before enrollment;
• • 4. Patients with severe hepatic and renal dysfunction;
• • 5. Patients with contraindications to CCTA examinations;
• • 6. Patients with poor initial CCTA image quality or data loss.