The Adjunctive Effect of a Titanium Brush in the Non-Surgical Treatment of Peri-Implantitis

Launched by UNIVERSITAT INTERNACIONAL DE CATALUNYA · Feb 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment approach for peri-implantitis, a condition that causes inflammation and bone loss around dental implants due to plaque buildup. The researchers want to see if using a special tool called a titanium brush, along with standard cleaning methods, can improve the effectiveness of treatment. The goal is to find out if this method can lead to better outcomes in terms of clinical signs, X-ray results, and bacteria levels.

To participate in this study, you need to be at least 18 years old and have a titanium dental implant that shows signs of peri-implantitis, such as bleeding and bone loss. You should also have a good level of oral hygiene and a healthy history regarding gum disease. Participants can expect to follow the study procedures closely and provide consent to take part. It's important to note that certain conditions, like untreated gum disease or smoking more than 10 cigarettes a day, may exclude you from joining the trial. If you're interested, this study could help improve treatments for people dealing with peri-implantitis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients with ≥18 years of age.
• • Ability to understand all the study procedures and to comply with them along the entire study period. Ability and willingness to give written informed consent.
• • An adequate level of oral hygiene (plaque index ≤ 25%) (O'Leary et al., 1972).
• • Treated periodontal disease.
• • Presence of at least one titanium implant with peri-implantitis \[i.e., presence of bleeding and/or suppuration on gentle probing with probing depth of ≥6 mm, and progressive bone loss. In the absence of initial radiographs, a bone level ≥2 mm apical to the most coronal part of the intrabony portion of the implant will be used as threshold of disease (Romandini et al., 2021)\].
• • Horizontal and vertical peri-implant bone defects.
• • Implant function time ≥ 1 year.
• • Presence of ≥2mm of keratinized peri-implant mucosa.
• • Screw-retained single and multiple restorations.
• Exclusion Criteria:
• • Untreated periodontitis.
• • Smokers \> 10 cigarettes per day.
• • Local or systemic diseases that would interfere with routine periodontal therapy (i.e., uncontrolled diabetes mellitus, cancer, HIV, chronic high-dose steroid therapy, metabolic bone disease, radiation, immunosuppressive disease, hepatic dysfunction, immunosuppressive disease, autoimmune disease).
• • Pregnant or lactating women.
• • Previous surgical and non-surgical treatment of affected implants at least 12 months prior to the beginning of the study.
• • Radiographic peri-implant bone loss \> two-thirds.
• • Mobility of the implant.
• • Known allergy or intolerance to macrolides.
• • Use of systemic antibiotics during the last 3 months.
• • Need of endocarditis prophylaxis.