Application of 68GA-labeled CD73 Targeting Probe PET/CT Imaging in the Diagnosis of Malignant Tumor

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · Feb 19, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new imaging method called 68Ga-DOTA-dPNE PET/CT to help identify malignant tumors, which are cancerous growths. The goal is to see how well this imaging technique can show where tumors are located in the body by highlighting a specific protein called CD73 that may be linked to the tumors. This could help doctors not only diagnose cancer more accurately but also understand how patients might respond to certain cancer treatments.

To participate in this trial, you need to be at least 18 years old and expected to live for at least 12 weeks. You should have a measurable tumor that hasn’t been treated with radiation or chemotherapy yet, and you must be able to provide written consent to join. However, women who are pregnant, breastfeeding, or planning to have children during the study cannot participate. If you join the study, you can expect to undergo a special scan that takes about thirty minutes, during which you will need to lie still. This trial is not yet recruiting participants, so it's important to keep an eye out for updates if you think you might be eligible.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1: Age: ≥18 years, expected survival ≥12 weeks 2: Without radiotherapy and chemotherapy, surgery or biopsy is feasible to obtain pathological diagnosis 3: Standard Solid Tumor Response Evaluation Criteria (RECIST) version 1.1 with at least one measurable target lesion 4: Obtain written informed consent and be able to follow up
• Exclusion Criteria:
• • - 1: Severe liver and kidney dysfunction. 2: Women who are planning to conceive, pregnant, or breastfeeding, as well as those planning to have children during the study period, are not eligible to participate in this research. Women of childbearing potential must use effective contraception throughout the course of the study.
• • 3: Individuals unable to lie flat for thirty minutes. 4: Suffers from claustrophobia or other mental illnesses 5: Researchers believe that the subject has other conditions that make them unsuitable for inclusion in this study 6: Refuses to join this clinical study