Postoperative Delirium After Intraoperative Ephedrine Versus Norepinephrine
Launched by RIVERSIDE UNIVERSITY HEALTH SYSTEM MEDICAL CENTER · Feb 19, 2025
Trial Information
Current as of July 01, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at how two different medications, ephedrine and norepinephrine, given during surgery, affect the chance of patients experiencing postoperative delirium (POD), which is confusion or disorientation that can happen after surgery. The researchers want to see if one medication leads to more or less delirium than the other. The study is not yet recruiting participants, meaning they haven't started enrolling patients yet.
To be eligible for this study, participants must have had a specific type of surgery and received either ephedrine or norepinephrine on the day of that surgery. However, patients who have undergone certain types of surgeries, received both medications that day, or have a history of confusion or dementia are not eligible. If you or a loved one are interested in this research, you can expect to contribute to important information that could help improve care for future surgical patients.
Gender
ALL
Eligibility criteria
- Ephedrine group:
- Inclusion Criteria:
- • underwent surgery (CPT code 1003143)
- • administered ephedrine on the day of surgery
- Exclusion Criteria:
- • received both vasopressors (ephedrine and norepinephrine) on the day of surgery.
- • patients who underwent neurology and neuromuscular surgery, cardiac surgery, and cardiac procedures
- • patients who were administered epinephrine or dopamine on the day of surgery
- • patients who were administered ephedrine or norepinephrine at any time within the 7 days following the day of surgery
- • a prior history of disorientation (ICD-10 code R41.0) or unspecified dementia (F03)
- Norepinephrine group:
- Inclusion Criteria:
- • underwent surgery (CPT code 1003143)
- • administered norepinephrine on the day of surgery
- Exclusion Criteria:
- • received both vasopressors (ephedrine and norepinephrine) on the day of surgery.
- • patients who underwent neurology and neuromuscular surgery, cardiac surgery, and cardiac procedures
- • patients who were administered epinephrine or dopamine on the day of surgery
- • patients who were administered ephedrine or norepinephrine at any time within the 7 days following the day of surgery
- • a prior history of disorientation (ICD-10 code R41.0) or unspecified dementia (F03)
About Riverside University Health System Medical Center
Riverside University Health System Medical Center (RUHS) is a leading healthcare institution committed to advancing medical research and improving patient outcomes through innovative clinical trials. As a comprehensive medical facility, RUHS integrates cutting-edge technology and a multidisciplinary approach to deliver high-quality care while actively engaging in research initiatives across various therapeutic areas. The center is dedicated to fostering collaborations with academic institutions and industry partners, ensuring that trials are conducted with the highest ethical standards and scientific rigor. Through its robust clinical trial program, RUHS aims to contribute to the development of new therapies and enhance the understanding of complex medical conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported