Vessel Imaging Using Optical Coherence Tomography for Plaque Morphology and Vessel Fractional Flow Reserve

Launched by MEDICAL UNIVERSITY OF WARSAW · Feb 19, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to understand and diagnose heart artery conditions, specifically focusing on patients with a type of heart disease called chronic coronary syndrome. The researchers are using a special imaging technique called optical coherence tomography (OCT) to get detailed pictures of the arteries and the plaque inside them. By comparing these images to a test that measures how well blood flows through the arteries, they hope to see how accurately the OCT can help doctors assess the severity of the blockage in the arteries.

To participate in this trial, you need to be at least 18 years old and have been diagnosed with chronic coronary syndrome, which might include symptoms like chest pain or positive results from certain heart stress tests. You should also have a moderate blockage (40-80%) in your coronary arteries. If you join the study, you will undergo some imaging tests and possibly some blood flow tests. The trial is currently looking for participants, so if you're eligible and interested, you could contribute to important research that may improve how heart conditions are diagnosed and treated in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years or older
• • Chronic coronary syndrome defined as presence of chest pain ranked 2-3 in the Canadian Cardiovascular Society classification or positive ischemia test (exercise test, single photon emission tomography (SPECT)
• • Intermediate grade coronary stenosis of 40-80% assessed visually in coronary angiography and OCT examination The patient is willing to participate in the study and has provided a written informed consent
• Exclusion Criteria:
• • Acute coronary syndrome
• • Proximal left main lesion
• • Ostial right coronary artery lesion
• • Bypass of the assessed vessel
• • Contraindications for adenosine administration
• • Hemodynamic instability
• • Heart insufficiency in New York Heart Association (NYHA) class IV scale
• • Acute renal insufficiency
• • Pregnancy