Re-ablation of Persistent Atrial Fibrillation

Launched by AARHUS UNIVERSITY HOSPITAL · Feb 20, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different treatments for patients with persistent atrial fibrillation, a heart condition that causes an irregular heartbeat. The researchers want to find out if a combination of treatments—pulmonary vein re-isolation along with an additional procedure called Vein of Marshall ethanol ablation, and blockages of certain heart areas—works better than just the pulmonary vein re-isolation alone. This trial will follow participants for up to five years to see how their heart rhythm improves and how their quality of life changes after the treatment.

To be eligible for this trial, participants need to be over 18 years old and have already had a previous procedure to treat their atrial fibrillation. They should have experienced at least two episodes of symptoms in the past year. The trial is not yet recruiting participants, but it aims to include both men and women who meet these criteria. Those who join will have regular check-ups with heart tests to monitor their progress and assess their quality of life over time. If you or a loved one are considering participation, it’s important to know that certain health conditions may disqualify someone from joining, such as recent heart surgery or uncontrolled high blood pressure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Previous pulmonary vein isolation for atrial fibrillation
• • Indication for catheter ablation with at least two episodes of symptomatic PsAF during the last 12 months
• • Age \> 18 years
• • Expected survival \> 12 months
• • Able to provide informed consent
• Exclusion Criteria:
• • Previous extrapulmonary atrial ablation other than cavotricuspid isthmus line, roof- or dome line or posterior wall isolation/ablation
• • Atypical atrial flutter in addition to atrial fibrillation
• • Atrial fibrillation secondary to a transient abnormality
• • Uncontrolled hypertension
• • Acute coronary syndrome, cardiac surgery, or TIA/stroke within the last 3 months
• • Planned cardiac surgery within 1 year
• • Dialysis or severe renal failure
• • Active substance or alcohol abuse (\>14 units/week)