Impact of Thyroid Treatment on Ovarian Function and Pregnancy Outcomes in Women with Differentiated Thyroid Cancer

Launched by ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL · Feb 19, 2025

Keywords

ClinConnect Summary

This clinical trial is looking to understand how different treatments for thyroid cancer can affect the ability of women to have children. Specifically, it will study how surgeries and radioactive iodine treatment (RAIT) impact the ovaries and pregnancy outcomes for women aged 20 to 45 who have been diagnosed with differentiated thyroid cancer, like papillary or follicular thyroid cancer. The researchers want to find out if factors such as age, hormone levels, and the presence of certain antibodies might influence ovarian health and the chances of having a successful pregnancy.

To participate in this study, women must be between 20 and 45 years old, be premenopausal, and have a confirmed diagnosis of differentiated thyroid cancer at an early stage. However, there are some conditions that would exclude someone from joining, such as having other cancers, certain uterine problems, or past surgeries that could affect their ovaries or pregnancy. If eligible, participants can expect to undergo assessments to help researchers understand the links between thyroid treatment and reproductive health, contributing valuable information that could help future patients.

Gender

FEMALE

Eligibility criteria

• Inclusion criteria:
• • 1. Age 20-45 years old;
• • 2. Premenopausal women whose thyroid B-ultrasound + surgical pathology is clearly differentiated thyroid cancer (papillar thyroid cancer or follicular thyroid cancer);
• • 3. TNM stage is in stage I (T1-3, N0 or N1, M0);
• • 4. Treatment of thyroid tumor resection: unilateral lobe of the thyroid + isthmus resection, total thyroidectomy, total thyroidectomy + RAIT.
• Exclusion criteria:
• • 1. Patients with malignant tumors in other parts or low undifferentiated thyroid cancer;
• • 2. Patients with abnormal liver and kidney function;
• • 3. TNM stage II and above;
• • 4. History of ovarian surgery, hysterectomy, pelvic surgery or radiation therapy;
• • 5. Pregnancy;
• • 6. Have the following uterine abnormalities, such as uterine malformation (single-horned uterus, double uterus); untreated mediastinal uterus, submucosal uterine fibroids, multiple endometrial polyps, or severe uterine adhesion.
• • 7. Patients diagnosed with polycystic ovary syndrome by the Rotterdam standard;
• • 8. Patients with ovarian failure;
• • 9. Patients have infectious factors, immune diseases and metabolic diseases that may affect pregnancy outcomes;
• • 10. Pregnancy contraindications or diseases that have a clear impact on pregnancy.