Longitudinal Quantitative Neuromuscular MRI in Neuropathic Patients

Launched by ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE · Feb 20, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how a special type of MRI, called quantitative neuromuscular MRI (qMRI), can help us understand and monitor certain nerve and muscle disorders. These conditions include Charcot-Marie-Tooth Neuropathy Type 1A, hereditary transthyretin amyloid neuropathy, and acquired demyelinating neuropathy. The trial aims to see if qMRI can provide more sensitive measurements of changes in muscle fat and nerve damage over time, which is important for assessing how well treatments are working.

To participate in this study, you should be between 18 and 80 years old and have a confirmed diagnosis of one of the neuropathies mentioned. Participants will undergo MRI scans to help researchers gather information about their muscle and nerve health. It's important to note that individuals with certain medical conditions or devices, such as pacemakers, may not be able to join the study. This research hopes to improve how we monitor these conditions, potentially leading to better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female between 18 and 80 years of age,
• • Patients who have freely given their consent to participate in this study,
• • Patient with genetically confirmed hereditary CMT neuropathy
• • or patient with an acquired demyelinating neuropathy such as typical PIDC or anti-MAG of typical form
• • or a patient with a genetically confirmed pathogenic mutation in the transthyretin (TTRn) gene,
• • Patients who are beneficiaries or entitled beneficiaries of a social security scheme.
• Exclusion Criteria:
• • Patients with co-morbidity or a history of other peripheral neuropathy,
• • Patients with alcohol or psychoactive substance abuse,
• • Patients with contraindications to MRI exploration: claustrophobia, pacemakers, Holter systems, IUDs, metal surgical clips, metal prostheses or implants (or other metal foreign bodies),
• • Patient unable to perform the MRI due to severe handicap,
• • Patient in a period of exclusion from another research protocol at the time of signing the consent/non-opposition form,
• • Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code (minors, adults under guardianship or trusteeship, patients deprived of their liberty, pregnant or breast-feeding women),
• • Persons who cannot read and understand the French language well enough to be able to give their consent to participate in research.