Spatial Memory and Temporal Lobe Epilepsy

Launched by CENTRE HOSPITALIER METROPOLE SAVOIE · Feb 21, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how temporal lobe epilepsy (TLE) affects memory, particularly the ability to remember locations and navigate spaces. People with TLE often experience a type of memory loss called accelerated forgetting, which can make it hard for them to remember things over time. The researchers want to compare the memory performance of adults with TLE to healthy volunteers of similar age and gender to see if there are significant differences in how they remember spatial information.

To participate, you need to be over 18 years old, right-handed, and free from any known neurological conditions. If you are a healthy volunteer, you’ll be matched with someone who has TLE based on age and gender. Participants will undergo a series of memory tasks, including a navigation task, to evaluate their memory skills. It’s important to know that individuals who are pregnant, left-handed, or have certain cognitive disorders will not be eligible for the study. Overall, this trial aims to better understand the relationship between temporal lobe epilepsy and memory, which could help improve care for individuals with this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• - healthy volunteers meeting each of the following criteria:
• • Aged over 18 years
• • Right-handed\*
• • Free of known neurological pathology
• • Signed consent
• * Matched in age (+ or - 5 years) and gender with epileptic patients presenting the characteristics below:
• • Right-handed\*
• • adult
• • presenting temporal lobe epilepsy, whose lateralization of the epileptogenic focus (right or left) has been objectified by an examination (EEG and/or MRI),
• • having carried out a neuropsychological assessment including the navigation task,
• • having been informed of the study, and consenting to the processing of their data
• Exclusion Criteria:
• • Person referred to in Article L1121-5 of the Public Health Code: Pregnant, parturient, or breastfeeding women
• • Person referred to in Article L1121-6 of the Public Health Code: persons deprived of their judicial or administrative freedom
• • Person referred to in Article L1121-8 of the Public Health Code: persons subject to a legal protection measure or unable to express their consent
• • Person referred to in Article L1121-8-1 of the Public Health Code: persons not affiliated to a social security scheme
• • Left-handed participants
• • Participants familiar with the premises of the Centre Hospitalier Métropole Savoie
• • Not speaking French
• • Exclusion criteria
• • Patients who have undergone epilepsy neurosurgery between the initial visit and the secondary visit of the neuropsychological assessment will not be paired with a healthy volunteer. Their data will not be studied.
• • Volunteers whose pretest scores reveal a cognitive disorder (pathological threshold \> 1.65) will not perform the navigation task. They will then be referred to a neurologist.