Genetic Risk Factor for Heat Stroke

Launched by UNIVERSITY OF IOWA · Feb 20, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how being a carrier of the Cystic Fibrosis (CF) gene might affect the risk of dehydration and other fluid-related issues in adults. The researchers want to understand if people who carry this gene are more likely to experience problems with electrolytes (important minerals in the body) when they are exposed to heat. The study will involve two main parts: the first part will include 100 CF carriers and 100 people without the gene, who will answer questions about their health and how they handle heat. The second part will involve a smaller group of 50 participants who will undergo a heat challenge by sitting in a sauna for 45 minutes to see how their bodies respond.

To be eligible for this study, participants must have already been tested and identified as either a CF carrier or a control (someone without the gene). They should be comfortable speaking and reading English. However, individuals who have been diagnosed with CF, diabetes, or certain heart conditions, or who are currently pregnant or taking specific medications, will not be able to participate. This trial is not yet recruiting, but once it begins, participants can expect to engage in surveys and a sauna session to help researchers gather important information about how the CF carrier state affects heat-related health risks.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Previously genotyped as a CF carrier or control
• • Comfortable speaking/reading English
• Exclusion Criteria:
• • Previously genotyped as a CF patient
• • Diagnosis of Type 1 or Type 2 diabetes
• • History of heart attack, stroke, heart failure, or atherosclerosis
• • Currently pregnant
• • Currently taking beta blockers or diuretics
• • Prisoner status
• • Unable to provide own written informed consent