Effect of Hysteroscopic Metroplasty on Reproductive Outcome in Patients with RIF

Launched by SHANGHAI FIRST MATERNITY AND INFANT HOSPITAL · Feb 21, 2025

Keywords

ClinConnect Summary

This study in Shanghai is testing whether adding a brief, camera-guided look inside the uterus (hysteroscopy) and, if needed, a small reshaping procedure (hysteroscopic metroplasty using cold scissors) can improve pregnancy chances for people who have had several failed embryo transfers. Participants are randomly assigned to either receive the extra hysteroscopy (with the option of metroplasty if a problem is found) or to go straight to embryo transfer without the extra procedure. The aim is to see if this approach improves pregnancy rates and other pregnancy outcomes within about 18 months after the last embryo transfer.

Who can join? Women aged 20–40 who have had at least two previous embryo implantation failures and are willing to try another embryo transfer. Exclusions include certain uterine problems, severe adenomyosis, premature ovarian failure, BMI over 35, or serious health issues. If you enroll, you’ll be followed for up to 18 months after your last embryo transfer to track pregnancy, biochemical pregnancy, clinical pregnancy, fetal implantation, and miscarriage. The study is currently enrolling by invitation at Shanghai First Maternity and Infant Hospital, and it is not testing drugs or devices regulated by the FDA. Results are not yet available.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • At least twice previous implantation failures
• • Willing to receive further embryo transfer
• Exclusion Criteria:
• • Sturctural intrauterine lesions
• • Severe adenomyosis
• • Premature ovarian failure
• • BMI \> 35 kg/m\^2
• • Severe systemic disease or maligant tumor