The Potential Effect of the Local Administration of Vitamins C and E on Orthodontic Treatment: a Randomized Clinical Trial

Launched by UNIVERSITY OF BAGHDAD · Feb 21, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring whether local injections of vitamins C and E can improve the effectiveness of orthodontic treatment, particularly in moving teeth and reducing side effects like pain and root resorption (damage to the roots of teeth). The study will involve patients who are starting orthodontic treatment with braces and will be divided into three groups: one will receive a saline solution (a saltwater injection), another will get vitamin C, and the last group will receive vitamin E. These injections will be given every two weeks for six months while the patients are undergoing their orthodontic treatment. Researchers will measure how quickly the teeth move, any pain experienced, and changes in the health of the gums and bone around the teeth.

To participate in the trial, individuals should be 12 years old or older and need braces due to moderate to severe crowding of the front teeth. Certain health conditions, like previous orthodontic work or specific dental issues, may exclude potential participants. During the trial, patients can expect regular check-ups and monitoring of their treatment progress. This research aims to find out if these vitamins can safely make orthodontic treatments more effective and comfortable for patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients aged 12 years and above, who are indicated for fixed appliance orthodontic treatment.
• • 2. Patients with moderate to severe crowding (4-9 mm) of the mandibular anterior teeth as per the Little's Irregularity Index (LII).
• • 3. 4. Treatment with or without two mandibular first premolars extraction. Presence of all the mandibular permanent teeth, except the third molars.
• • 5. The overbite and overjet should not impede bracket placement on the mandibular anterior teeth.
• Exclusion Criteria:
• • 1. History of previous orthodontic intervention.
• • 2. History of trauma or root resorption in the mandibular anterior teeth.
• • 3. Presence of mandibular anterior teeth crowding of less than 4 mm or greater than 9 mm (LII).
• • 4. Existence of blocked-out teeth precluding engagement with the aligning archwire.
• • 5. History of systemic diseases, especially diabetes and bone diseases.
• • 6. Patients with periodontitis and obvious loss of tooth attachment according to Plaque and Bleeding on Probing indices.
• • 7. Pregnant and lactating mothers.
• • 8. Mouth breathing patients and smokers.
• • 9. Healthy patients who have not used any medications (such as anti-inflammatory or antimicrobial drugs) or supplements (such as vitamins)