Antimicrobial Effect of Curcumin Versus Chlorohexidine on Oral Microbiome

Launched by CAIRO UNIVERSITY · Feb 22, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of curcumin, a natural compound found in turmeric, on the oral health of individuals at high risk for dental issues like cavities and plaque. The study aims to see how well a mouthwash containing curcumin can help reduce harmful bacteria in the mouth compared to a traditional mouthwash called chlorhexidine. Researchers believe that curcumin's antibacterial properties could offer a safer and more accessible alternative for preventing dental caries, especially for those who may not have easy access to dental care.

To participate in this trial, volunteers aged 21 to 45 who are considered at high risk for dental caries are welcome. Participants must agree to a one-year follow-up and provide informed consent. However, individuals who are undergoing orthodontic treatment, have gum disease, are smokers, pregnant, or have certain disabilities cannot take part in the study. If eligible, participants will use the mouthwash and provide saliva samples to help researchers understand how well curcumin works in improving oral health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Provide informed consent.
• • Patients accept the one-year follow-up period.
• • Cooperative patients.
• • The study recruited volunteers of both genders
• • Age from 21 to 45 years
• • Patients classified at high risk of caries
• Exclusion Criteria:
• • Patients undergoing orthodontic treatment.
• • Periodontal compromised patients.
• • Smokers.
• • Pregnant women.
• • Patients with physical or mental disability
• • Patient with removable prosthesis