Inflammatory and Metabolic Prognostic Assessment in Critically Ill Neurological Patients

Launched by YAN ZHANG · Feb 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how to better predict the outcomes for patients with serious neurological conditions like stroke, encephalitis, or other severe brain injuries who are receiving a special type of feeding called enteral nutrition. Researchers want to create a tool that doctors can use to identify patients who are at higher risk for complications. By understanding certain markers related to inflammation and metabolism, the goal is to provide more personalized nutritional support to improve patient care.

To be eligible for this trial, participants need to be between 18 and 80 years old and have been admitted to the Neuro Intensive Care Unit (NICU) within a week of their illness. They should have a specific level of brain function and meet other health criteria. Importantly, participants must agree to join the study, either themselves or through a legal representative. If someone joins the trial, they can expect to receive close monitoring and care while their nutritional needs are assessed over at least a week. This study has not started recruiting participants yet, so there will be more information available once it begins.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 18 and 80 years, no gender restrictions.
• • 2. Within 7 days of disease onset and expected NICU stay of at least 7 days.
• • 3. Eligible for enrollment within 24 hours of NICU admission, with enteral nutrition (EN) initiated and continued for at least 7 days.
• • 4. Non-traumatic severe brain injury patients (including cerebrovascular disease and encephalitis) with a Glasgow Coma Scale (GCS) score ≤12.
• • 5. NRS 2002 score ≥3.
• • 6. Kuwata drinking test ≥ grade 3.
• • 7. Acute Gastrointestinal Injury (AGI) grade 1 or 2.
• • 8. Signed informed consent obtained from the patient or their legal representative.
• Exclusion Criteria:
• • 1. Severe malnutrition prior to admission, defined as BMI \< 16 kg/m².
• • 2. Pregnant or lactating women.
• • 3. Receiving hypothermia treatment or core body temperature \< 36°C.
• • 4. End-stage disease with an expected survival time of \< 48 hours, or severe dysfunction of the heart, lungs, or other vital organs, leading to hemodynamic instability.
• • 5. Malignant tumors.