Transcranial Magnetic Stimulation Synchronized with Motor Task Training for Post-Stroke Rehabilitation

Launched by FIRST AFFILIATED HOSPITAL OF THE CHINESE PEOPLE'S LIBERATION ARMY NAVAL MEDICAL UNIVERSITY · Feb 25, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring a treatment called repetitive transcranial magnetic stimulation (rTMS) combined with motor training to help people recover movement in their arms after a stroke. The researchers want to find out if this treatment can improve motor skills for individuals who can or cannot produce specific brain signals known as motor evoked potentials (MEPs). Participants will receive rTMS therapy for two weeks, along with brain scans and assessments to measure their progress before, during, and after the treatment.

To join the study, participants should be between 20 and 80 years old, have recently experienced a stroke that has affected their arm movement, and be stable enough to take part in various evaluations. They should also be able to understand and cooperate with the study process. If you or a loved one is interested, the study is currently looking for volunteers who meet these criteria. The trial aims to assess how safe and effective this new treatment can be for helping stroke recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The patient is first diagnosed with stroke through neurological examination, CT or MRI scan.
• • 2. The vital signs are stable and there is a certain degree of upper limb motor dysfunction.
• • 3. The age is between 20 and 80 years old.
• • 4. The cognitive ability is not significantly affected and the patient can cooperate with various examinations and assessments, with a MMSE score ≥ 20 points.
• • 5. There are no serious complications (such as pneumonia, heart failure, urinary tract infection or malnutrition).
• • 6. There is no pathological condition that is a contraindication for TMS in the medical history (for example, patients with metal in the brain, such as aneurysm clips, patients with a cardiac pacemaker, pregnant women, or those with a history of epileptic seizures).
• • 7. The patient or guardian agrees to sign the informed consent form.
• Exclusion Criteria:
• • 1. Patients with severe heart, lung, liver, kidney diseases and malignant tumors;
• • 2. Those with a history of aphasia, severe cognitive impairment or mental illness;
• • 3. Patients who have had a history of epileptic seizures in the last month or are taking anti-epileptic drugs recently;
• • 4. Those with severe visual or hearing impairments, unable to communicate normally;
• • 5. People with metal implants, pacemakers, skull defects or other conditions that prevent them from undergoing TMS.