Effect of Nonsurgical Periodontal Treatment on Apelin and Oxidative Stress Levels

Launched by HATICE YEMENOĞLU · Feb 25, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how nonsurgical treatment for gum disease, known as periodontitis, affects certain markers in the body related to inflammation and oxidative stress. Periodontitis is a serious gum condition that can lead to tooth loss and is linked to other health issues like diabetes and heart disease. Researchers are particularly interested in a substance called apelin, which may help indicate the presence of periodontitis and how the body responds to treatment. By measuring levels of apelin and other related markers in the saliva and blood before and after treatment, the study aims to better understand the relationship between gum health and overall body health.

To participate in this study, individuals need to be between 65 and 74 years old, have at least 20 teeth, and have been diagnosed with periodontitis. They should also be generally healthy, not pregnant or breastfeeding, and not have had any recent periodontal treatment or used certain medications. Participants can expect to undergo nonsurgical treatment for their gum disease and will have their apelin levels and other health markers monitored during the study. This research could provide valuable insights into how to effectively diagnose and treat gum disease in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Being systemically healthy
• • Not smoking
• • Not using anti-inflammatory drugs in the last 3 months, antibiotics and systemic corticosteroids in the last 6 months
• • Not being pregnant or lactating
• • Not having received periodontal treatment in the last 6 months
• • Having at least 20 teeth in the mouth
• • Being diagnosed with periodontitis (Stage 1-2 and Stage 3-4) by the researcher
• • Working groups will be formed based on the 2017 Periodontal Disease Classification
• Exclusion Criteria:
• • being periodontally healthy having systemic disease being pregnant and lactating smoking having periodontal treatment in the last 6 months having fewer than 20 teeth