Efficacy of Selective Laser Trabeculoplasty Targeting Nasal Versus Inferior 180-degree

Launched by MAYO CLINIC · Feb 24, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called Selective Laser Trabeculoplasty (SLT) for people with open angle glaucoma, a condition that affects the eye and can lead to vision loss. The researchers want to see if targeting different areas of the eye—specifically the nasal area versus the inferior area—makes a difference in how well the treatment works. The trial is currently recruiting participants who are 18 years old or older and have been diagnosed with glaucoma or are at risk for it due to high eye pressure.

To take part in the study, individuals should have certain characteristics, such as having high eye pressure measured multiple times in the past and experiencing mild to moderate vision issues. Participants will receive the SLT treatment, and the study will monitor their progress over time. It's important to note that individuals who have had prior eye surgeries (except for cataracts done more than six months ago) or certain medical conditions may not be eligible to join. This study aims to improve how we manage open angle glaucoma, potentially leading to better outcomes for patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 years and older
• • Ability to comprehend the study procedures and agreement to proceed with primary SLT treatment
• • Diagnosis of primary or secondary open angle glaucoma or glaucoma suspects with ocular hypertension
• • Bilateral disease
• • Pre-SLT IOP \>21 mmHg measured at least twice during patient's lifetime with or without medication
• • Open angles with moderate to intense trabecular pigmentation
• • Mild to moderate visual field defects (24-2 standard mean deviations better than the Swedish interactive thresholding algorithm standard of 12 dB)
• • No adequate IOP control (low treatment compliance, substantial adverse effects with eyedrops, and at least 2 IOP measurements higher than the individualized target IOP)
• Exclusion Criteria:
• • Unwilling or unable to give consent
• • Unable to attend scheduled post-operative visits
• • Previous history of either laser treatment or intraocular surgery, except for non-complicated cataract surgery (performed \>6 months before SLT)
• • History of ocular trauma
• • Narrow angles
• • Retinal detachment
• • Active iris neovascularization or active proliferative retinopathy
• • Active uveitis
• • Monocular patients
• • Current use of steroids (ocular, periocular, or systemic)