Magnetic Resonance Imaging in Patients with Trigeminal Neuralgia

Launched by TONGJI HOSPITAL · Feb 24, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how brain changes might relate to a painful condition called trigeminal neuralgia (TN). TN causes severe facial pain, and this study will use MRI (a type of scan that takes detailed images of the brain) to examine how the brain's structure and connections change in these patients. The goal is to understand these changes better and how they might connect to the pain and symptoms that patients experience.

To participate in this trial, individuals must be diagnosed with TN and have not found relief from standard medications like carbamazepine or oxcarbazepine. They should be right-handed and have no significant loss of sensation in their face. Unfortunately, people with certain conditions, such as other types of chronic pain or a history of head trauma, cannot join. If eligible, participants can expect to undergo an MRI to help researchers learn more about the brain's response to TN and potentially improve treatment options in the future. The trial is not yet recruiting, but it aims to gather important information about this challenging condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The diagnosis was TN according to the ICHD.
• • Patients requiring surgical treatment due to ineffective or intolerant treatment with carbamazepine or oxasepine before operation;
• • First surgical treatment;
• • Right-handed dominant;
• • There was no significant loss of sensation
• Exclusion Criteria:
• • Secondary TN;
• • Associated with other types of chronic pain or neuropsychiatric disorders;
• • History of head trauma or stroke or cerebrovascular ischemia;
• • History of microvascular decompression or other treatments (gamma knife radiosurgery, etc.);
• • Unable to cooperate independently;
• • Contraindications, such as uncontrolled infection, coagulopathy, etc.;
• • MRIcontraindications (e.g., pacemaker, claustrophobia, etc.)