Oral Ketorolac for IUD Pain Reduction

Launched by UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL · Feb 24, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether taking oral ketorolac, a type of pain reliever, before getting an intrauterine device (IUD) can help reduce pain during the insertion process. The trial is specifically looking at how the timing of the medication might affect the level of pain that women experience when they have the IUD placed.

To participate in this trial, you need to be a woman aged 18 or older who wants to have an IUD inserted and is able to give consent. However, some people won’t be eligible, such as those who are currently pregnant, have certain medical conditions, or are taking specific medications that could interfere with the study. If you join the trial, you can expect to take the medication at different times before your IUD insertion, and your pain levels will be closely monitored during the procedure. The trial is not yet recruiting participants, but it aims to help improve the experience of women getting IUDs by finding effective ways to manage pain.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 18 years or older
• • Able to consent
• • Desires IUD insertion
• Exclusion Criteria:
• • IUD placement under sedation or oral anxiolytic
• • IUD replacement (removal with insertion)
• • Daily narcotic or NSAID use
• • Contraindications to IUD placement
• • Current: pregnancy, genital/pelvic infection
• • Lifetime history: uterine anomaly, pelvic inflammatory disease, allergy to levonorgestrel or copper
• • Contraindications to ketorolac
• • Current: weight under 50 kilograms
• • Lifetime history: allergy to NSAIDs, liver disease, renal disease, peptic ulcer disease, cerebrovascular bleeding, gastrointestinal bleeding