The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

Launched by BRIGHAM AND WOMEN'S HOSPITAL · Feb 28, 2025

Keywords

ClinConnect Summary

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study is looking at how to better understand heart problems, particularly for people who experience chest pain or shortness of breath. The study will use a special type of imaging called cardiac magnetic resonance imaging (MRI) to measure blood flow to the heart during a stress test that mimics exercise. This research aims to find out if these detailed blood flow measurements can provide more accurate diagnoses of heart disease compared to standard imaging techniques. It’s hoped that by understanding blood flow better, doctors can determine how severe a patient's heart condition is and tailor treatment accordingly.

To participate in this study, you need to be between the ages of 35 and 85 and have experienced symptoms that led to a referral for a stress cardiac MRI, like chest pain or an abnormal heart test suggesting coronary artery disease. You should also be at intermediate or high risk for significant heart issues due to factors like age, diabetes, high blood pressure, or a family history of heart disease. If you qualify, you can expect to undergo the MRI procedure, which is non-invasive and will help researchers gather important information about heart health. The study is not yet recruiting participants, but it’s an exciting opportunity for those who meet the criteria to potentially contribute to better heart disease diagnosis and treatment in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. male or female at age 35-85 years,
• 2. presence of either of the following sign/symptom that led to a referral to stress cardiac magnetic resonance imaging:
• • 1. chest pain or anginal equivalent, or
• • 2. abnormal electrocardiogram with a suspicion of coronary artery disease
• 3. Intermediate or high risk of significant coronary disease based on at least 1 of the following conditions:
• • a) patient age \> 45 for male, 50 for female b) Diabetes, hypertension, or hypercholesterolemia: by either history or medical treatment c) family history of premature coronary disease: first degree relative at age \<= 55 male and \<=65 female d) history of smoking of \> 10 packed-years e) post-menopausal state \>5 years f) any chronic inflammatory conditions d) Body mass index \> 30 e) Any medical documentation of coronary or peripheral artery disease
• Exclusion Criteria:
• • 1. Acute myocardial infarction within the past 30 days prior to cardiac magnetic resonance imaging
• 2. Confirmed diagnosis of any significant non-coronary cardiac conditions below:
• • 1. any severe-grade valvular heart disease,
• • 2. left ventricular ejection fraction \<40% from any known non-coronary causes,
• • 3. infiltrative cardiomyopathy,
• • 4. hypertrophic cardiomyopathy,
• • 5. pericardial disease with significant constriction, or
• • 3. active pregnancy,
• • 4. any competing conditions leading to an expected survival of \< 2 years
• • 5. contraindication to vasodilator (regadenoson or adenosine)
• • 6. metallic device or object that poses an magnetic resonance imaging safety hazard
• • 7. metallic device with a high likelihood of non-diagnostic cardiac magnetic resonance images