The Value of Combined Detection of Different Blood Biomarkers in the Diagnosis and Treatments of Traumatic Brain Injury

Launched by FIRST AFFILIATED HOSPITAL XI'AN JIAOTONG UNIVERSITY · Feb 25, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating the use of different blood tests, called biomarkers, to help diagnose and treat traumatic brain injuries (TBI). TBIs can lead to serious long-term health issues, and finding ways to identify and treat them early is crucial. Researchers believe that measuring specific biomarkers in the blood can help doctors better understand how severe the injury is and determine the best treatment options for patients.

To be eligible for the trial, participants must be between the ages of 18 and 65 and have experienced an acute brain injury within the last 24 hours. The severity of their injury will be assessed using a scale that measures their level of consciousness. It’s important for potential participants to know that those with a history of neurological disorders, substance abuse, or other significant injuries will not be included in the study. While the trial is not yet recruiting participants, it aims to explore how blood tests can improve the care and recovery of people who have suffered TBIs.

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ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age: 18-65 years old
• • 2. Time of injury: patients with acute traumatic brain injury within 24h
• • 3. Glasgow Coma Scale (Glasgow Coma Scale, GCS) score: 13 to 15 for patients with mild traumatic brain injury, 9 to 12 for moderate traumatic brain injury, and 3 to 8 for patients with severe traumatic brain injury
• • 4. No other system damage has occurred
• • 5. Admitted to hospital for the first diagnosis after the injury
• Exclusion Criteria:
• • 1. With a history of neurological or psychiatric disorders
• • 2. Traumatic brain injury occurred before the injury
• • 3. History of alcohol or substance abuse
• • 4. Mild brain trauma is a complication of other injuries (systemic trauma, facial trauma, or spinal cord trauma) or other causes (psychological trauma, language impairment)
• • 5. Patients without visits, and incomplete data during treatment