Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation

Launched by BEIJING FRIENDSHIP HOSPITAL · Feb 27, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating the use of a medication called terlipressin to help manage blood pressure during kidney transplantation surgeries. The researchers want to see if terlipressin can do a better job than the standard treatment (a drug called dobutamine) in keeping blood pressure stable while performing the surgery. They will compare how well both treatments work in terms of blood pressure control, how well the kidney functions after the transplant, and any complications that may arise.

To participate in this trial, you need to be at least 18 years old and have end-stage renal disease, which means your kidneys are not working well enough to take care of your body's needs. People who are having multiple organ transplants, are allergic to the study medication, are pregnant, or have certain other health issues may not be eligible. If you join the study, you will receive either terlipressin or the standard treatment during your surgery, and the team will monitor your health closely throughout the process. Your safety and well-being are the top priority in this research.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Patients with end-stage renal disease aged 18 years or above
• Exclusion Criteria:
• • simultaneous multiple organ transplantation
• • known allergy to study medication
• • known pregnancy status
• • cancellation of surgery due to grafts or personal reasons
• • persistent severe preoperative hypertension that may not require intraoperative supportive therapy with vasoactive medications
• • any other reason that the supervising physician or the anesthesiologist on duty think the patient is not suitable for the study