Vitamin K and Cognition in Coronary Heart Disease (NutriCog)

Launched by MONTREAL HEART INSTITUTE · Feb 25, 2025

Keywords

ClinConnect Summary

The NutriCog trial is a study that aims to understand how vitamin K (VK) supplementation might improve thinking skills and blood vessel health in older adults who have stable coronary heart disease (CHD). This study will look at adults aged 60 and older who do not consume vitamin K supplements and have a daily diet that includes less than 150 micrograms of vitamin K. Participants should also be able to exercise moderately for about 2.5 hours a week and understand French or English well enough to give informed consent.

If you qualify and choose to participate, you will be part of a pilot study that will assess the effects of vitamin K on your cognitive performance. It’s important to note that some individuals, such as those with recent heart problems, certain heart conditions, or cognitive impairment, will not be eligible for this study. The trial is not yet recruiting participants, but it could provide valuable insights into how vitamin K might benefit those with coronary heart disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men and women
• • Age 60 years and older
• • Medically documented stable Coronary Heart Disease (CHD)
• • Daily dietary intakes of phylloquinone \<150 mcg
• • Non-consumption of vitamin K supplements (i.e. K1 or K2, singly or in combination with other nutrients), or other cognitive aids
• • Good French or English understanding
• • Physical exercise not exceeding 2.5 hours/week of moderate to vigorous aerobic activity
• • Capacity and willingness to sign informed consent
• Exclusion Criteria:
• • Recent acute coronary syndrome (\<3 months) or recent coronary revascularization (bypass surgery or percutaneous coronary intervention, \<3 months)
• • Known left ventricular dysfunction (LVEF \< 40%) or chronic heart failure
• • Recent modification of medication (\<2 weeks)
• • Warfarin (Coumadin) use
• • Cognitive impairment (based on telephone version of the Mini-Mental State Examination test, score \<19/23)
• • Diagnosis of depression or uncontrolled anxiety
• • Malabsorption disorder (advanced liver disease, Crohn's disease)
• • Patient with auditory or vision impairments not properly corrected by glasses or hearing aids
• • Unable to read the informed consent form or unable to understand the oral explanations provided by the assessor