Autologous Point-of-Care Adipose Therapy: Delayed Injury/Scar

Launched by UNIVERSITY OF PITTSBURGH · Feb 26, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to treat scars that form after severe burns or injuries. Specifically, researchers want to find out if a method called autologous layered composite grafting, which involves using the patient’s own fat, is just as effective as traditional skin grafting for improving scars. The goal is to see if this new method can help heal wounds better, reduce scarring, and lower the risk of infections.

To participate in the trial, you need to be an adult aged 18 or older and willing to undergo a procedure to release and reconstruct your scar. The study will include both men and women, including military veterans. If you join, you will receive fat grafting at the same time as having a skin graft to help with the healing process. However, if you have certain health issues, an active infection, or are pregnant, you may not be eligible for the study. The trial is not yet recruiting participants, but it aims to help those with challenging scars find better treatment options.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The proposed study will include adult patients 18 years of age or older,
• • male or female,
• • civilian, military, active duty or retired veterans
• • presenting for scar contracture release and reconstruction at any level.
• • Additional inclusion criteria includes willingness to be randomized to receive a fat graft.
• Exclusion Criteria:
• • Age \< 18 years of age,
• • active infection,
• • medical co-morbidities or anatomic configuration deemed by the physician to be a concern for safety,
• • unwilling or unable to comply with study procedures,
• • radiation to the site of interest,
• • prisoners and/or vulnerable populations.
• • In addition, candidates that are pregnant or plan to become pregnant in the next year, will be excluded.