Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol

Launched by FEDERAL UNIVERSITY OF SÃO PAULO · Feb 27, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different treatments to help manage knee pain caused by osteoarthritis, a condition that can make it hard to move and enjoy everyday activities. The trial compares continuous ablative radiofrequency, which uses heat to block pain signals, and chemical denervation, where a special alcohol is injected to help reduce pain. Participants will be randomly assigned to receive one of these treatments, and their pain levels, ability to move around, and overall quality of life will be tracked over time to see which method works better.

To be eligible for this study, you need to be at least 18 years old and have been experiencing knee pain for more than three months. You’ll also need a confirmed diagnosis of knee osteoarthritis through imaging tests like X-rays or MRIs. However, if you've had major knee surgery before or have certain health issues that could complicate the procedure, you may not qualify. If you decide to participate, you can expect to receive one of the two treatments and will be monitored closely to assess how well it helps with your pain and daily activities. This trial has not yet started recruiting participants, so it’s a good idea to stay informed about when it begins.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged ≥ 18 years.
• • Knee pain for more than 3 months.
• • Clinical and imaging-confirmed diagnosis of knee osteoarthritis, based on X-ray, ultrasound, or magnetic resonance imaging (MRI).
• Exclusion Criteria:
• • History of major joint interventions, such as previous knee surgery or arthroplasty.
• • Severe joint effusion.
• • Coagulation disorders or other clinical contraindications for the procedure.
• • Uncontrolled comorbidities that increase procedural risk.
• • Body mass index (BMI) \> 35.
• • Cognitive impairment that affects the ability to understand and respond to pain assessment instruments.