Therapeutic Effect of Proliferative Therapy (prolotherapy) on Pain Using Injectable Hypertonic Dextrose 25% Versus Injectable Dextrose 10% in Retrodiscal Tissues in Patients with Anterior Disc Displacement with Reduction: a Randomized Clinical Trial .

Launched by CAIRO UNIVERSITY · Mar 2, 2025

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ClinConnect Summary

This clinical trial is studying a treatment called prolotherapy, which involves injecting a solution to help relieve pain in the jaw joint, specifically for patients with a condition known as TMJ disc disorder. The trial will compare two types of injections: one with a stronger solution of dextrose (a type of sugar) and another with a lower concentration. The goal is to see which treatment is more effective in reducing pain and improving function for people experiencing discomfort or clicking sounds in their jaw, especially when opening or closing their mouth.

To be eligible for this study, participants must have specific symptoms of TMJ dysfunction, such as pain or difficulty opening their mouths, along with audible clicking sounds in the joint. However, certain individuals will not be included, such as those with previous jaw surgery, infections in the area, or allergies to the injection components. The trial is not yet recruiting participants, but once it starts, those who qualify can expect to receive either of the two types of injections and will be monitored for their pain levels and jaw function over time.

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Eligibility criteria

• Exclusion criteria:
• • The clinical or radiographic signs of disc displacement without reduction .
• • A history of allergic reactions to any components of the injectable solution.
• • Blood dyscrasias and systemtic diseases .
• • Previous surgery of the affected joint.
• • Infection in pre-auricular area
• Inclusion criteria:
• • Patients should have one or more signs and symptoms of these
• • Symptoms: Patients who report typical symptoms of TMJ dysfunction, such as pain, discomfort, or clicking sounds in the joint, especially when opening or closing the mouth.
• • Mouth Opening: Limited range of motion or difficulty with full mouth opening .
• • Clicking: Audible clicking.
• • Pain: Pain or tenderness around the TMJ, often radiating to the ear, temple, or neck