Impact of Chromium Supplementation on Glucido-lipidic Metabolism, Oxidative Stress and Inflammatory State in Patients with Gestational Diabetes

Launched by UNIVERSITY OF KASDI MERBAH · Mar 1, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of chromium supplements on pregnant women who have gestational diabetes, a condition that can affect blood sugar levels during pregnancy. The researchers want to find out if taking chromium, in doses of 200 µg or 400 µg daily, can help improve the way the body processes sugars and fats, reduce inflammation, and balance oxidative stress (which is an imbalance between free radicals and antioxidants in the body). They will also check if these supplements are safe for both the mother and the baby. Participants will take the supplements for six weeks and will have regular check-ups to monitor their health.

To be eligible for the study, women must be pregnant and around 28 weeks along, either healthy or diagnosed with gestational diabetes but without any other serious health problems. If you qualify and choose to participate, you will receive either the chromium supplement or not, and your health will be closely monitored throughout the trial. It’s also important to note that all participants will receive standard iron and vitamin recommendations during their pregnancy. This study aims to provide valuable insights into whether chromium supplementation can be beneficial for women with gestational diabetes.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• * Healthy pregnant women:
• • Whose their gestational age is 28 weeks
• • They have no pathology or complication associated with their pregnancy.
• * Pregnant women with gestational diabetes mellitus:
• • They will be selected according to the criteria of the one-step method for screening for gestational diabetes mellitus established by the WHO.
• • They have no other pathology or complication associated with pregnancy.
• • They are subjected to insulin therapy and a low-calorie diet, rich in protein, fiber and beneficial lipids (they will all asked to keep their medical treatment prescribed by their doctor).
• • All women involved in this study will be systematically supplemented with 60 mg/d iron and 400 mg/d vitamin B9 during pregnancy as recommended by WHO.
• Exclusion Criteria:
• • Pregnant women with unrecognized diabetes, type I or type II, will not be involved in this study.
• • Pregnant women who were supplemented before one month or during pregnancy, or who will need other micronutrient supplements during the study to avoid their influence on the results.
• • Pregnant women who develop other health complications will be removed from the study and replaced by others.
• • Women with gestational diabetes mellitus who were unable to complete chromium supplementation up to 6 weeks will be excluded from the study and replaced by others.