Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis

Launched by AIN SHAMS UNIVERSITY · Mar 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a tool called the Perfusion Index (PI) can help doctors decide when to start a specific treatment called vasopressors for patients with sepsis and septic shock. Sepsis is a serious condition that happens when the body has a severe response to an infection, leading to symptoms like fever, low blood pressure, and confusion. By monitoring the PI, which gives information about blood flow in the body, doctors hope to improve the timing of treatments for patients who are very ill in the Intensive Care Unit (ICU).

To be eligible for this study, patients must be in the ICU and show signs of sepsis or septic shock, such as having low blood pressure that does not improve with fluids. However, certain individuals cannot participate, including pregnant women, patients already on vasopressors, and those with specific health issues affecting blood flow. If you or a family member qualify, you can expect to be monitored closely as part of this important research, which aims to enhance treatment options for a critical condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - All ICU patients with clinically suspected sepsis and septic shock ( signs include fever hypotension oliguria and confusion combined with culture results showing infection .Septic shock is a subset of sepsis involves persistent hypotension (mean arterial pressure ≥ 65 mm Hg, and a serum lactate level \> 18 mg/dL \[2 mmol/L)not responding to fluid resuscitation ) .
• Exclusion Criteria:
• • Pregnant females
• • Patients on vasopressor or positive inotropic drugs
• • Patients with hypothermia (defined as central temperature \<35°C).
• • Patient with impairment of upper extremity circulation,(such as those who underwent radial artery harvesting for coronary artery bypass grafting or had suspected occlusion of the radial artery prior to surgery,)
• • Patients had undergone an operation that involved the large arteries of the aortic arch.
• • Patients with atherosclerosis .