A Prospective Study Evaluating the Impact of Conservative Management on Retained Products of Conception and EMV

Launched by FU XING HOSPITAL, CAPITAL MEDICAL UNIVERSITY · Mar 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a conservative treatment approach can help women who have retained products of conception (RPOC) after a miscarriage or delivery. RPOC can happen when some tissue from the pregnancy remains in the uterus, and the trial aims to find out if combining conservative treatment with enhanced blood flow to the uterus can help the body naturally resolve this issue. Participants will receive treatments like mifepristone or other supportive care after being diagnosed with RPOC and will be monitored for two menstrual cycles to see how effective the treatment is.

To be eligible for this study, participants should be women who have recently experienced a miscarriage or delivery within the last eight weeks and are willing to try conservative management. They should be in stable health and able to provide consent. However, women experiencing heavy bleeding, infections, severe organ issues, or certain other medical conditions may not qualify. If you join this study, you can expect regular check-ins and support as you undergo the treatment, and your progress will be carefully monitored.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Recent history of miscarriage or delivery (within the past 8 weeks)
• • Strong willingness to undergo conservative management
• • Hemodynamically stable
• • Signed informed consent form
• Exclusion Criteria:
• • Heavy vaginal bleeding (requiring immediate surgical intervention)
• • Active pelvic or systemic infection (e.g., fever \>38°C, elevated CRP/WBC)
• • Severe dysfunction of vital organs (heart, liver, or kidney)
• • Known drug allergies or contraindications to proposed medications (e.g., misoprostol intolerance)
• • Suspected ectopic pregnancy or gestational trophoblastic disease (confirmed by ultrasound or β-hCG levels)
• • Placenta accreta spectrum disorders diagnosed during current pregnancy
• • History of uterine artery embolization