A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension

Launched by KARDIGAN, INC. · Mar 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a medication called tonlamarsen to see if it can help lower blood pressure in adults who have high blood pressure that isn’t well controlled, even while taking two or more other blood pressure medications. The trial is looking for adults aged 18 to 80 who weigh at least 50 kg and have a specific range of blood pressure levels. To be eligible, participants should have high blood pressure that remains above 135 mmHg despite their current treatment.

If you or someone you know is interested in participating, the trial is currently recruiting. Participants will receive tonlamarsen and will be monitored to see how well it works in lowering their blood pressure. It’s important to note that individuals with certain health conditions or a history of not consistently taking their medications may not be eligible for this study. This trial aims to provide new options for those struggling to manage their blood pressure effectively.

Gender

ALL

Eligibility criteria

• Key Inclusion Criteria:
• • Age 18 to 80, body weight ≥ 50 kg
• • Has uncontrolled hypertension while receiving between 2 and 5 antihypertensive medications prescribed for hypertension
• • Has mean office seated systolic blood pressure \> 135 to ≤ 170 mmHg
• Key Exclusion Criteria:
• • Has known history of secondary hypertension
• • Has documented history of poor adherence to antihypertensive medication
• • Has unstable/underlying known cardiovascular disease
• • Has abnormal thyroid function with clinical significance