Genicular Nerve Phenol Neurolysis Versus Radiofrequency Ablation for Pain Relief in Grade 4 Knee Osteoarthritis

Launched by AIN SHAMS UNIVERSITY · Mar 6, 2025

Keywords

ClinConnect Summary

This clinical trial is looking to find out which method is better for relieving knee pain in patients with severe osteoarthritis (Grade 4 knee osteoarthritis). Specifically, it compares two treatments: one that uses a chemical called phenol to block pain nerves and another that uses radiofrequency ablation, a technique that uses heat to disrupt nerve signals. Participants in this study will be assessed for pain relief using a simple pain scale and a knee function score over a period of 16 weeks.

To be eligible for this trial, participants must have been diagnosed with Grade 4 knee osteoarthritis and have not found relief from other pain management methods. However, individuals who have had knee replacement surgery, have certain heart conditions, infections, allergies to study medications, bleeding disorders, or psychiatric illnesses will not be able to participate. This trial is currently not recruiting participants, but it aims to help improve pain management options for those suffering from debilitating knee pain.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Grade 4 knee osteoarthritis according to Kellgren-Lawrence radiological classification.
• • Failure to manage pain with conservative methods.
• Exclusion Criteria:
• • Prior knee replacement
• • Patients with cardiac pacemakers or implantable cardiac defibrillators.
• • Septic knee or systemic sepsis.
• • Allergy to any of the drugs used in the study.
• • Coagulopathy or patients on anticoagulants.
• • Patients with psychiatric illness.