Muscle Cramps in Hemodialysis Patients: A Randomized Controlled Trial

Launched by UNIVERSITY OF YALOVA · Mar 4, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at ways to help reduce muscle cramps in patients who are receiving hemodialysis, a treatment for kidney failure. Muscle cramps can be quite uncomfortable and affect daily life, so this study will test two non-drug methods: massage therapy and progressive muscle relaxation exercises. These methods are thought to help relax the muscles and potentially lessen the frequency and intensity of cramps. The trial aims to gather evidence on how effective these approaches are in improving the quality of life for hemodialysis patients.

To participate in this study, individuals need to be between 18 and 75 years old and have been on hemodialysis for at least six months, experiencing muscle cramps at least twice a week. They should also be in stable health, without major heart issues or severe medical conditions. Participants will be asked to attend regular sessions where they will learn and practice the massage and relaxation techniques. It’s important to note that some individuals, such as those with certain chronic illnesses or active infections, will not be eligible to join the study. Overall, this trial aims to explore helpful solutions for managing an uncomfortable side effect of hemodialysis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Receiving Hemodialysis Treatment: Patients who have been undergoing regular hemodialysis treatment for at least six months.
• • History of Muscle Cramps: Patients who have experienced muscle cramps at least twice a week in the past month.
• • Age Range: Between 18 and 75 years old. Must be able to swallow tablets Cognitive and Physical Suitability: Having the cognitive and physical capacity to understand and perform massage and progressive muscle relaxation exercises.
• • Stable Cardiovascular Condition: No history of myocardial infarction or severe cardiovascular complications in the past three months.
• • Stable Medical Condition: No acute or severe medical conditions other than dialysis treatment.
• • Voluntary Participation: Signing the informed consent form after being fully informed about the study.
• Exclusion Criteria:
• • Insulin dependent diabetes Thyroid disease Clinical diagnosis of Alzheimer's Disease
• • Neuromuscular Disorders: Presence of conditions such as multiple sclerosis, Parkinson's disease, or peripheral neuropathy.
• • Severe Cardiovascular Diseases: History of myocardial infarction, congestive heart failure (NYHA class III-IV), or uncontrolled hypertension in the past three months.
• • Severe Orthopedic or Rheumatic Conditions: Severe osteoarthritis, rheumatoid arthritis, or other chronic musculoskeletal disorders.
• • Acute Infections or Inflammatory Conditions: Diagnosis of an active infection or inflammatory disease during the study period.
• • Mental or Psychiatric Disorders: Presence of severe cognitive impairment, dementia, or major depression/anxiety.
• • End-Stage Cancer Diagnosis: Undergoing active cancer treatment or having metastatic cancer.
• • Contraindications to Massage or Relaxation Exercises: Presence of skin infections, open wounds, or any medical condition preventing massage or exercise application.
• • Regular Use of Alternative Therapies: Engaging in regular massage therapy, yoga, or similar relaxation techniques within the past three months.
• • Pregnancy: Being pregnant or in the breastfeeding period. Inability to Comply with the Study: Difficulty in attending the study regularly or adhering to the assigned interventions.