Evaluating Dyspnea in Autoimmune Myasthenia Gravis "why Am I Short of Breath?"

Launched by INSTITUT DE MYOLOGIE, FRANCE · Mar 4, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "Evaluating Dyspnea in Autoimmune Myasthenia Gravis," is looking into why individuals with myasthenia gravis (MG) experience shortness of breath, which can happen during activities, while resting, or even at night. The goal is to understand the different factors that contribute to this breathing difficulty, known as dyspnea. By identifying the causes, researchers hope to find better ways to help manage this symptom, improve patients' quality of life, and prevent serious complications related to breathing.

To be part of this study, participants must be at least 18 years old and have a confirmed diagnosis of autoimmune myasthenia gravis. They should also experience some level of shortness of breath in their daily life. However, individuals who are pregnant, have other serious breathing problems, recently had a respiratory infection, or are currently in a crisis with their MG may not be eligible. Participants will need to sign a consent form and should be connected to a social security program. The trial is not yet recruiting, but it aims to gather important information that could lead to improved care for those living with MG and breathing difficulties.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18
• • Confirmed diagnosis of autoimmune MG
• • Shortness of breath in daily life: score 1 or 2 on the respiration item on the MG- activities of daily living score
• • Signed consent form
• • Affiliated to or beneficiary of a social security scheme
• Exclusion Criteria:
• • Known Pregnancy
• • Known respiratory disorder (other than MG)
• • Recent (within past 4 weeks) respiratory infection
• • Current MG crisis or exacerbation (necessitating increase in MG medication \&/or hospital admission)
• • No dyspnea - score 0 or 3 on the respiration item on the MG- activities of daily living score
• • Severe cognitive impairment/guardianship