Bowel Sound in Predicting the Severity of Acute Pancreatitis: Protocol of a Prospective, Multi-center Study

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · Mar 4, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how monitoring bowel sounds can help predict the severity of acute pancreatitis (AP), a condition where the pancreas becomes inflamed. Some patients with AP develop severe acute pancreatitis (SAP), which can lead to serious health issues. By using special equipment to continuously listen to bowel sounds for at least 48 hours, researchers hope to find an early way to identify patients who might develop SAP. This could help doctors intervene sooner and improve patient outcomes.

To participate in the study, individuals must be between 18 and 85 years old and have been diagnosed with acute pancreatitis within the last 48 hours. They also need to have certain symptoms or test results that indicate AP. However, people with serious conditions that require immediate surgery or those with specific health issues, like certain chronic diseases or allergies to certain materials, will not be eligible. Participants can expect to have their bowel sounds monitored and analyzed, which could provide valuable insights into their condition and help improve care for future patients.

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Eligibility criteria

• Inclusion criteria:
• • 1. Aged between 18 and 85 years old.
• • 2. Meet the diagnostic criteria for AP, at least two of the following three: (a) characteristic abdominal pain; (b) serum amylase and lipase levels are greater than three times the upper limit of normal; (c) abdominal images with typical manifestations of AP.
• • 3. AP patients within 48 hours of onset.
• • 4. The patient or family members understand the study protocol and sign the informed consent form.
• Exclusion criteria:
• The patients who fulfill any of the following criteria will be excluded:
• • 1. Patients with serious conditions requiring surgery and abdominal lavage.
• • 2. Pregnant women.
• • 3. The patients with muscle and nerve disorders, chronic pancreatitis, inflammatory bowel disease, cancer, and irritable bowel syndrome.
• • 4. The patients with severe digestive, respiratory, cardiovascular, hematological, endocrine, psychiatric, and infectious diseases.
• • 5. The patients have a history of abdominal surgery (except appendectomy or cholecystectomy).
• • 6. Allergic to silicone, polycarbonate materials or medical plaster. The intake of antibiotic, probiotics, and Chinese herbal medicine will be recorded before the collection of the swabs and will not be considered as exclusion criteria.