Endosonographic Shear Wave Elastography to Assess Liver and Splenic Fibrosis

Launched by PROVIDENCE MEDICAL RESEARCH CENTER · Mar 4, 2025

Keywords

ClinConnect Summary

Study design This is a single-center, prospective, non-randomized, comparative study which will compare the diagnostic accuracy of Endoscopic ultrasound guided shear wave elastography (EUS-SWE) with liver biopsy for liver fibrosis.

Patients who will undergo a standard-of-care EUS guided liver biopsy (or have clinically obvious liver cirrhosis) will be prospectively enrolled after obtaining informed consent. All enrolled patients will undergo EUS guided liver biopsy, unless they have an obvious diagnosis of cirrhosis. EUS-SWE of the liver and spleen.

In selected patients who have been refe...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \> 18 years (irrespective of sex)
• • Patients determined clinically to have liver cirrhosis needing EUS for other reasons
• • Patients determined clinically to be candidates for EUS guided liver biopsy
• • Elevated liver enzymes without obvious etiology
• • Clinical concern for cirrhosis requiring histological confirmation
• • Patients with known cirrhosis without diagnostic dilemma
• • Ability to provide informed consent and willing to participate
• Exclusion Criteria:
• • Surgically altered foregut anatomy which precludes safe endoscopic liver biopsy
• • Coagulopathy with INR greater than 1.6 in patients on anticoagulant therapy
• • Thrombocytopenia with platelet count less than 50,000/mL
• • Pregnancy (positive urine pregnancy test in females of childbearing age)