Multi-Center Study Protocol: Impact of Sarcopenia in Early-Onset Colorectal Cancer.

Launched by INSTITUTO DE INVESTIGACIÓN BIOMÉDICA DE SALAMANCA · Mar 5, 2025

Keywords

ClinConnect Summary

As reported by the GLOBOCAN study, EOCRC occurs in individuals younger than 50 years old. According to the GLOBOCAN estimates, there were 188,069 new cases of EOCRC, with an Age Standardized Incidence Rate (ASRs) of 2.9 per 100,000 person-years worldwide. Recent evidence suggested an increasing incidence rate for EOCRC in different populations, with greater changes in both developed and developing countries. Despite the declining trend in the incidence of CRC in the total population of the developed countries, the incidence rates for EOCRC were increasing both in the developed and developin...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Histologically confirmed EOCRC
• • Emergency room access for suspected surgical pathology
• • Age: 18-49 years at diagnosis.
• • Available baseline CT or MRI scans for sarcopenia assessment
• Exclusion Criteria:
• • Presence of comorbidity conditions severely affecting muscle mass unrelated to cancer (e.g., neuromuscular disorders).
• • Inadequate follow-up data or loss to follow-up
• • No past oncological history