Ketone Ester And Salt (KEAS) in Older Adults

Launched by INDIANA UNIVERSITY · Mar 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of ketone supplements on older adults who consume a high-salt diet. High salt intake can lead to serious health problems, especially in people aged 50 to 85, such as high blood pressure and kidney issues. The researchers want to find out if taking ketones—substances that the body produces during exercise and low-calorie diets—can help protect against the harmful effects of too much salt. They hope that ketone supplements might improve blood pressure and overall cardiovascular health in people who are sensitive to salt.

To participate in the trial, you need to be between 50 and 85 years old, with a resting blood pressure no higher than 150/90 and a body mass index (BMI) below 35. You should also be free from certain health conditions like diabetes, heart disease, or cancer. If you join, you can expect to take ketone supplements and have your blood pressure, blood samples, and heart health monitored. This research could lead to new ways to protect older adults from the negative effects of high salt consumption.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Between the ages of 50-85
• • Resting blood pressure no higher than 150/90
• • BMI below 35 kg/m2 (or otherwise healthy)
• • Free of any metabolic disease (diabetes or renal), pulmonary disorders (COPD, severe asthma, or cystic fibrosis), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular), no autoimmune diseases, and no history of cancer
• • Do not have any precluding medical conditions (i.e. hemophilia) or medication (Pradaxa, Eliquis, etc.) that prevent participants from giving blood
• • Participants must be able to cycle on an exercise bike for up to one hour at a time.
• Exclusion Criteria:
• • High blood pressure - greater the150/90 mmHg
• • History of cardiovascular disease
• • History of cancer
• • History of diabetes
• • History of kidney disease
• • Obesity (BMI \> 30 kg/m2)
• • Current smoking, using smokeless tobacco, or vaping (within past 12 months)
• • Current pregnancy