Home-Based Respiratory Muscle Training Intervention for Reducing Symptoms in Stage I-III Lung Cancer Survivors

Launched by ROSWELL PARK CANCER INSTITUTE · Mar 4, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at whether breathing exercises that can be done at home might help survivors of early-stage lung cancer feel better and stay more active. Many people who have survived lung cancer struggle with breathing difficulties, fatigue, and lower fitness levels, especially after treatment. The goal of this study is to see if a program that focuses on strengthening the muscles used for breathing can help reduce these symptoms and improve quality of life. By staying active, survivors may also help their immune system fight cancer more effectively.

To qualify for this trial, participants need to be at least 18 years old and have a recent diagnosis of non-metastatic lung cancer (meaning the cancer hasn’t spread). They should have undergone surgery and finished all their cancer treatments, like chemotherapy or radiation. Participants will also need to be willing to provide a blood sample at home for the study. If someone is actively exercising or has certain medical conditions, they may not be eligible. Those who join the study can expect to engage in breathing exercises at home that are designed to strengthen their respiratory muscles and improve their overall well-being.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years of age.
• • Self-identify as non-Hispanic Black or White.
• • Are \< 15 months of histologically confirmed invasive, non-metastatic, lung cancer diagnosis.
• • Have received surgical treatment (primarily stage I, II and III) and have completed all cancer treatments (surgery, chemotherapy, radiation).
• • Willing to provide biospecimen samples for the study (blood) which will be collected in the comfort of the patient's home by a mobile phlebotomy group.
• • Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure.
• Exclusion Criteria:
• • Participant is metastatic (stage IV) at study entry.
• • Has contraindications for respiratory muscle training (e.g., recent pulmonary embolism, aortic aneurysm, current pneumothorax).
• • Is actively engaging in a structured exercise program and/or meeting exercise guidelines.
• • Unwilling or unable to follow protocol requirements.
• • Any condition which in the investigator's opinion deems the participant an unsuitable candidate to participate in the study.